Factor vii or viia polypeptide variants

Details Factor vii or viia polypeptide variants Factor vii or viia polypeptide variants

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/36 (2006.01) A61P 7/04 (2006.01) C07K 14/745 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2483478

The present invention relates to novel polypeptide variants of factor VII (FVII) or factor VIIa (FVIIa) polypeptides, where said variants comprise an amino acid substitution in position 10 and 32 and where said variants further comprise a sugar moiety covalently attached to an introduced in vivo N- glycosylation site located outside the Gla domain. Such polypeptide variants are useful in therapy, in particular for the treatment of a variety of coagulation-related disorders, such as trauma.

La présente invention concerne de nouveaux variants polypeptidiques des polypeptides du facteur VII (FVII) ou du facteur VIIa (FVIIa), lesquels variants comprennent une substitution d'acides aminés en position 10 et 32 et renferment en outre un fragment de sucre attaché par covalence à un site de N-glycosylation in vivo introduit situé à l'extérieur du domaine Gla. Les variants polypeptidiques de l'invention sont utilisés en thérapie, en particulier dans le traitement d'une variété de troubles liés à la coagulation, comme les traumas.

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