Factor vii polypeptides that are modified and uses thereof

Details Factor vii polypeptides that are modified and uses thereof Factor vii polypeptides that are modified and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01)

Patent

CA 2721038

Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor Vila and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activi-ty, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.

Cette invention concerne des polypeptides facteur VII modifiés et leurs utilisations. Ces polypeptides FVII modifiés comprennent le Facteur Vila et d'autres formes du Facteur VII. Parmi les polypeptides FVII modifiés décrits, il y a ceux qui ont des activités altérées, typiquement une activité pro-coagulante altérée, comprenant des activités pro-coagulantes accrues. De ce fait, ces polypeptides modifiés sont des agents thérapeutiques.

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