Factor viii c2 domain variants

Details Factor viii c2 domain variants Factor viii c2 domain variants

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/37 (2006.01) A61P 7/04 (2006.01) C07K 14/745 (2006.01) C07K 14/755 (2006.01) C12N 15/09 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2462966

Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients after being treated with factor VIII. Modified factor VIII is disclosed in which the amino acid sequence is changed by a substitution at one or more of the specific loci. The modified factor VIII si useful for hemophiliacs, either to avoid or prevent the action of inhibitory antibodies.

Des locus spécifiques d'acide aminé du facteur humain VIII interagissent avec des anticorps d'inhibition de patients hémophiles ayant subi un traitement au moyen du facteur VIII. L'invention concerne un facteur VIII modifié dans lequel la séquence d'acide aminé est modifiée par une substitution au niveau d'au moins un locus parmi les locus spécifiques. Le facteur VIII modifié est utile pour des hémophiles, soit de manière à éviter, soit de manière à empêcher l'action d'anticorps d'inhibition.

Affiliated with

Also associated with

Rating

Factor viii c2 domain variants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Factor viii c2 domain variants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Factor viii c2 domain variants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1733869