Factor viii polymer conjugates

Details Factor viii polymer conjugates Factor viii polymer conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01) C07K 14/755 (2006.01)

Patent

CA 2730714

The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. In one embodiment of the invention, the water-soluble polymer is selected from the group consisting of polyethylene glycol (PEG), polysialic acid (PSA) or dextran.

La présente invention concerne une construction protéique comprenant une molécule de facteur VIII qui est conjuguée à un polymère hydrosoluble via des parties de glucide de facteur VIII. L'invention porte en outre sur des procédés de préparation de ladite construction.

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