Factor viii polypeptide

Details Factor viii polypeptide Factor viii polypeptide

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 9/19 (2006.01) A61K 38/37 (2006.01) A61P 7/04 (2006.01) C07K 14/755 (2006.01) C07K 16/36 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2514646

The application discloses Factor VIII polypeptides comprising internal deletions of amino acids within the area of residues 741 to 1689, wherein the thrombin cleavage sites at about 741 and about 1689 are present, and a site at about 1648 is not present, as compared to human Factor VIII.

La présente invention a trait à des polypeptides de Facteur VIII comportant des délétions internes d'acides aminés au sein de la zone de résidus 741 à 1689, dans laquelle sont présents les sites de restriction de thrombine aux environs du résidu 741 et aux environs du résidu 1689, et un site aux environ du résidu 1648 n'est pas présent, par rapport au Facteur VIII humain.

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