Factor xa inhibitors

Details Factor xa inhibitors Factor xa inhibitors

C - Chemistry, Metallurgy

07

D

C07D 409/14 (2006.01) A61K 31/4439 (2006.01) A61K 31/495 (2006.01) A61K 31/54 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2651303

The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

La présente invention concerne des composés de formule (I) et leurs sels, esters, et promédicaments pharmaceutiquement acceptables qui sont inhibiteurs de facteur Xa. La présente invention concerne également des intermédiaires utilisés dans la fabrication de tels composés, des compositions pharmaceutiques contenant un tel composé, des procédés de prévention ou de traitement de diverses pathologies caractérisées par une thrombose indésirable et des procédés d'inhibition de la coagulation d'un prélèvement sanguin.

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