C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C12N 5/06 (2006.01) C12P 21/06 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2290778
Two FADD-like anti-apoptotic proteins that regulate Fas/TNFR1- or UV-induced apoptosis are disclosed. Nucleotide sequences encoding the proteins are disclosed as are methods of using the nucleic acid molecules and making the proteins. Pharmaceutical compositions and methods of using the same are disclosed. Reagents, kits and methods of identifying compounds that inhibit anit-apoptotic activity of the proteins and methods of identifying compounds that inhibit binding activity of the proteins are disclosed.
Cette invention concerne deux protéines anti-apoptose et de type FADD qui permettent de réguler l'apoptose déclenchée par le Fas/RFNT1 ou par les UV. Cette invention concerne également des séquences de nucléotides codant ces protéines, ainsi que des procédés d'utilisation des molécules d'acide nucléique et de fabrication de ces protéines. Cette invention concerne aussi des compositions pharmaceutiques et des procédés d'utilisation de ces dernières. Cette invention concerne enfin des réactifs, des nécessaires et des procédés d'identification de composés qui inhibent l'activité anti-apoptose des protéines, ainsi que des procédés d'identification des composés qui inhibent la capacité de liaison de ces protéines.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Thomas Jefferson University
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