Family of high affinity antibodies for cancer treatment

Details Family of high affinity antibodies for cancer treatment Family of high affinity antibodies for cancer treatment

C - Chemistry, Metallurgy

12

N

167/100, 167/40,

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2000913

This invention concerns a family of chimeric antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG72) of human origin. These antibodies have (1) high affinity animal V H and V L sequences which mediate TAG-72 binding and (2) human C H and C L regions. They are thought to produce significantly fewer side-effects when administered to human patients by virtue of their human C H and C L antibody domains. The nucleotide and amino acid sequences of V H.alpha.TAG V H, CC46 V H, CC49H, CC83 V H, and CC92 V H, and CC49L, CC83 V L, and CC92 V L idiotype sequences are disclosed, as well as in vivo methods of treatment and diagnostic assay using these chimeric antibodies.

Cette invention porte sur une famille d'anticorps chimères ayant une grande affinité avec un antigène glycoprotéinique syalilaté associé à des tumeurs, de poids moléculaire élevé (TAG72) d'origine humaine. Ces anticorps ont (1) des séquences V H et V L animales d'affinité élevée qui assurent la médiation de TAG-72 liant, et (2) des régions C H et C L humaines. On croit qu'ils produisent beaucoup moins d'effets secondaires lorsqu'ils sont administrés à des patients humains à cause de leurs régions humaines d'anticorps C H et C L. Sont décrites les séquences de nucléotides et d'acides aminés de V H.alpha.TAG V H, CC46 V H, CC49H, CC83 V H et CC92 V H et les séquences idiotypiques CC49L, CC83 V L et CC92 V L, ainsi que des méthodes in vivo de traitement et de diagnostic faisant appel à ces anticorps chimères.

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