C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
150/3.3, 150/15.
C12Q 1/48 (2006.01) C12N 9/10 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2040529
Assays for farnesyl-protein transferase (FT) which can be used to identify substances that block the farnesylation of ras oncogene products are described. Because farnesylation is required for ras oncogene activity, inhibitory compounds identified in the assays of the invention can block neoplastic transformation mediated by the ras oncogene. The assays of the invention are targeted for a step subsequent to the synthesis of farnesyl pyrophosphate (FPP), the donor of the farnesyl residue, and an intermediate in cholesterol synthesis and other important cellular pathways. Therefore, compounds which inhibit ras mediated transformation, yet do not cause major disruptions of important cell pathways that require FPP as an intermediate may be identified using the assays of the invention.
Barbacid Mariano
Manne Veeraswamy
Barbacid Mariano
Manne Veeraswamy
Osler Hoskin & Harcourt Llp
LandOfFree
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