Farnesyl transferase inhibitors

Details Farnesyl transferase inhibitors Farnesyl transferase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/12 (2006.01) A61K 31/40 (2006.01) A61P 35/02 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2387579

This invention relates to compounds of formula (I) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation.

L'invention concerne des composés de la formule (I) inhibant la farnésylation de produits géniques par inhibition de l'enzyme farnésyl-protéine transférase (FPTase). L'invention concerne également des méthodes de production des composés, des compositions pharmaceutiques et des méthodes de traitement de maladies, en particulier du cancer, lesquelles sont induites par farnésylation.

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