Farnesyl transferase inhibitors having a piperidine...

Details Farnesyl transferase inhibitors having a piperidine... Farnesyl transferase inhibitors having a piperidine...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07D 401/06 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2320233

The present invention relates to a novel piperidine derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts thereof, in which A, E and G are defined in the specification; to a process for preparation of the compound of formula (1); to an intermediate which is used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

Cette invention se rapporte à un nouveau dérivé de pipéridine représenté par la formule (I), qui possède une action inhibitrice contre la farnésyl-transférase, ou à des sels de ce dérivé acceptables sur le plan pharmaceutique. Dans cette formule, A, E et G sont définis dans les pièces descriptives de la demande de brevet. L'invention se rapporte également à un procédé de préparation de ce composé; à un intermédiaire servant à la préparation de ce composé; et à une composition pharmaceutique renfermant ce composé comme principe actif.

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