Farnesyl transferase inhibitors in combination with hmg coa...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/435 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01)

Patent

CA 2294399

The present invention relates to a pharmaceutical composition for the treatment of cancer or a benign proliferative disorder in a mammal, comprising an FTase inhibitor, an HMG CoA reductase inhibitor and a pharmaceutically acceptable carrier, wherein the FTase inhibitor and the HMG CoA reductase inhibitor are present in amounts that render the composition effective in the treatment of cancer of a benign proliferative disorder in a mammal. The present invention also relates to a pharmaceutical composition for inhibiting the abnormal growth of cells in a mammal, comprising an FTase inhibitor, an HMG CoA reductase inhibitor and a pharmaceutically acceptable carrier, wherein the FTase inhibitor and the HMG CoA reductase inhibitor are present in amounts that render the composition effective in the inhibitor of growth of abnormal cells in a mammal.

La présente invention concerne un procédé se rapportant au traitement anticancéreux chez un mammifère, et notamment les humains, et consistant en l'administration, à ce mammifère, d'un inhibiteur de FTase associé à un inhibiteur de HMG CoA réductase.

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