Fas antagonists and uses thereof

Details Fas antagonists and uses thereof Fas antagonists and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2174132

The present invention provides a panel of monoclonal antibodies and binding proteins which specifically bind to human Fas antigen. Some of the antibodies and binding proteins are capable of stimulating T cell proliferation, inhibiting binding of anti-Fas CH-11 monoclonal antibody to cells expressing Fas antigen, blocking anti-Fas CH-11 monoclonal antibody-mediated lysis of cells, and blocking Fas ligand- mediated lysis of cells. The invention also provides for therapeutic compositions comprising the monoclonal antibodies.

Groupe d'anticorps monoclonaux et de protéines de liaison se liant de manière spécifique à l'antigène Fas humain. Certains des anticorps et des protéines de liaison peuvent stimuler la prolifération de lymphocytes T, inhiber la liaison de l'anticorps monoclonal CH-11 anti-Fas aux cellules exprimant l'antigène Fas, bloquer la lyse cellulaire due à l'anticorps monoclonal CH-11 anti-Fas, et bloquer la lyse cellulaire due au ligand Fas. On a également prévu des compositions thérapeutiques comportant ces anticorps monoclonaux.

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