Fas ligand-fused proteins

Details Fas ligand-fused proteins Fas ligand-fused proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2410525

Provided by this invention is a fusion protein which is capable of binding to Fas, and which comprises a peptide comprising at least a part of the amino acid sequence of Fas ligand, a peptide having oligomerization ability, and a peptide which increases recombinant protein production. Also provided are a method for using the FLAG-like peptide for the purpose of increasing the production of the recombinant protein, and a method for using the FLAG-like peptide for the purpose of increasing the biological activity of the fusion protein of the leucine zipper and the transmembrane protein.

L'invention concerne des protéines de fusion se liant à Fas, qui comprennent des peptides contenant au moins une partie de la séquence d'acides aminés du Fas-ligand, des peptides pouvant former un oligomère et des peptides augmentant la productivité d'une protéine recombinante. L'invention concerne également un procédé d'utilisation d'un peptide de type FLAG permettant d'augmenter la productivité d'une protéine recombinante, ainsi qu'un procédé d'utilisation de ce peptide permettant d'augmenter l'activité biologique d'une protéine de fusion d'un domaine à glissière de leucine avec une protéine transmembranaire.

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