Fas ligand-like protein, its production and use

Details Fas ligand-like protein, its production and use Fas ligand-like protein, its production and use

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2260767

This invention relates to a Fas ligand-like protein having an apoptosis- inducing activity, etc. or its salt, a partial peptide of the protein or its salt; a DNA coding for the protein; a recombinant vector; a transformant; a method for producing the protein, a pharmaceutical composition comprising the protein, the partial peptide or its salt; and an antibody to the protein or the partial peptide. The protein, the partial peptide or its salt, and the DNA are useful as a prophylactic or therapeutic agent for cancer, viral infection, Helicobacter pylori infection, invasive staphylococcia, hepatitis, nephritis, bone disease, atherosclerosis or pain. The antibody can be used in assay of the protein, the partial peptide or its salt. The protein, the partial peptide or its salt is useful as a reagent for the screening for candidate medical compounds.

L'invention concerne une protéine similaire au ligand Fas, présentant une activité d'induction de l'apoptose, ou son sel, un peptide partiel de ladite protéine ou son sel; un ADN codant pour la protéine; un vecteur de recombinaison; un transformant; un procédé de production de ladite protéine, une composition pharmaceutique comprenant ladite protéine, le peptide partiel ou son sel; et un anticorps dirigé contre ladite protéine ou ledit peptide partiel. Ladite protéine, ledit peptide partiel ou son sel, et l'ADN sont utiles en tant qu'agent thérapeutique contre le cancer, l'infection virale, l'infection à hélicobacter pylori, la staphylococcie invasive, l'hépatite, la néphrite, les affections osseuses, l'athérosclérose ou la douleur. Ledit anticorps peut être utilisé dans l'analyse de la protéine, du peptide partiel ou de son sel. La protéine, le peptide ou son sel, sont utiles en tant que réactif pour la recherche de composés médicaux d'intérêt potentiel.

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