Fas peptide mimetics and uses thereof

Details Fas peptide mimetics and uses thereof Fas peptide mimetics and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/00 (2006.01) A61K 38/12 (2006.01) A61K 38/17 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2490542

Exocyclic peptide mimetics that disable Fas were developed. A three dimensional model of the Fas receptor-ligand complex was constructed and structurally predicted regions of the receptor that were relevant to binding ligand were used to create constrained peptide mimetics. Exocyclic anti-Fas peptide mimetics were identified that block Fas receptor-ligand interactions, and modulate Fas biological activity both in vitro and in vivo. The mimetics are useful, e.g., for treating Fas-related pathologies.

L'invention concerne des mimétiques peptidiques exocycliques qui désactivent Fas. On a construit un modèle à trois dimensions du complexe ligand-récepteur de Fas et on a utilisé des régions du récepteur structurellement prédites, pertinentes au ligand de liaison, pour créer des mimétiques peptidiques contraints. On a identifié des mimétiques peptidiques anti-Fas exocycliques qui bloquent les interactions ligand-récepteur de Fas et modulent l'activité biologique de Fas aussi bien in vitro qu'in vivo. Les mimétiques servent, par exemple, dans le traitement de pathologies liées à Fas.

Affiliated with

Also associated with

Rating

Fas peptide mimetics and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fas peptide mimetics and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fas peptide mimetics and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1813277