C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/20 (2006.01) A61K 31/495 (2006.01) A61P 25/18 (2006.01) C07D 237/24 (2006.01) C07D 409/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2674752
The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, forexample schizophrenia, by exerting an antipsychotic effect without motor side effects.
La présente invention porte sur des 4-aryl-6-pipérazin-1-yl-pyridazines substituées en position 3, qui sont des antagonistes du récepteur de la dopamine 2 se dissociant rapidement, sur des procédés de préparation de ces composés, sur des compositions pharmaceutiques comprenant ces composés comme ingrédient actif. Les composés trouvent utilité comme médicaments pour traiter ou prévenir des troubles du système nerveux central, par exemple la schizophrénie, en exerçant un effet anti-psychotique sans effets secondaires moteurs.
Bartolome-Nebreda Jose Manuel
Langlois Xavier Jean Michel
Macdonald Gregor James
Van Gool Michiel Luc Maria
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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