Fast-dissolving galanthamine hydrobromide tablet

Details Fast-dissolving galanthamine hydrobromide tablet Fast-dissolving galanthamine hydrobromide tablet

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2257431

The present invention is concerned with a fast-dissolving tablet for oral administration comprising as an active ingredient a therapeutically effective amount of galanthamine hydrobromide (1:1) and a pharmaceutically acceptable carrier, characterized in that said carrier comprises a spray-dried mixture of lactose monohydrate and microcrystalline cellulose (75:25) as a diluent, and a disintegrant; and with a direct compression process of preparing such fast- dissolving tablets.

Comprimé à dissolution rapide destiné à une administration orale, comprenant comme principe actif une dose thérapeutique efficace de bromhydrate de galanthamine (1.1) et un excipient pharmaceutiquement acceptable, caractérisé en ce que l'excipient comprend un mélange séché par atomisation de monohydrate de lactose et d'une cellulose microcristalline (75:25) comme diluant et un délitant; et procédé de compression directe destiné à la préparation de tels comprimés à dissolution rapide.

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