Fast-dissolving pharmaceutical composition comprising as-3201

Details Fast-dissolving pharmaceutical composition comprising as-3201 Fast-dissolving pharmaceutical composition comprising as-3201

A - Human Necessities

61

K

A61K 31/499 (2006.01)

Patent

CA 2306883

The present invention is directed to a fast-dissolving pharmaceutical composition comprising micronized (R)-2-(4- bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2- a]pyrazine-4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (hereinafter, referred to as AS-3201). The pharmaceutical composition of the present invention has improved dissolution characteristics as well as good bioavailability.

Composition médicamenteuse à dissolution rapide, qui contient sous forme de poudre le composé (R)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4-tétrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine-1,2',3,5'-tétraone (AS-3201). Cette composition se dissout facilement et présente une bonne biodisponibilité.

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