A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01)
Patent
CA 2535340
The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouthfeel. The tablets of the invention comprise a compound which melts at about 37~C or lower, have a low hardness, high stability and generally comprise few insoluble disintegrants which may cause a gritty or chalky sensation in the mouth. Convenient and economically feasible processes by which the tablets of the invention may be produced are also provided.
L'invention concerne des procédés de préparation de comprimés se dissolvant rapidement dans la bouche tout en procurant une remarquable sensation buccale. Les comprimés selon l'invention comprennent un composé fondant à une valeur égale ou inférieure à 37 ·C environ, présentant une faible dureté, une haute stabilité, et renfermant généralement peu de délitants insolubles susceptibles de causer une sensation granuleuse ou crayeuse dans la bouche. L'invention concerne en outre des procédés commodes et d'une mise en oeuvre économique, de production des comprimés selon l'invention.
Abu-Izza Khawla Abdullah
Kinter Kevin S.
Li Vincent H.
Szamosi Janos
Torys Llp
Wyeth
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