C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C12N 5/06 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2359041
Aminopyrimidine derivatives represented by general formula (I) which inhibit fat accumulation in fat cells and, therefore, are efficacious in preventing and treating various diseases in association with enlargement of fat tissues, wherein R1 represents hydrogen, alkyl, alkenyl, etc.; R2 and R3 represent each hydrogen, halogeno, alkyl, alkenyl, etc.; R5 represents hydrogen, alkyl, etc.; R6 represents C1-12 alkyl, C2-12 alkenyl, etc.; and X represents nitrogen, CH, etc.
La présente invention concerne des dérivés aminopyrimidines correspondant à la formule générale (I) dans lequel R?1¿ représente l'hydrogène, alkyle, alcényle etc.; R?2¿ et R?3¿ représentent chacun l'hydrogène, halogéno, alkyle, alcényle etc.; R?5¿ représente l'hydrogène, alkyle, etc.; R?6¿ représente alkyle en C¿1?-C¿12?, alcényle en C¿2?-C¿12?, etc.; et X représente l'azote, CH etc. Lesdits dérivés sont des inhibiteurs de l'accumulation de graisse dans les adipocytes et, par conséquent, sont efficaces pour la prévention et le traitement des différentes maladies associées à l'élargissement des tissus adipeux.
Murakami Hiroko
Ohtsubo Tsuguteru
Marks & Clerk
Sumitomo Chemical Company Limited
Sumitomo Pharmaceuticals Company Limited
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