Fat emulsions for inhalational administration

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/72 (2006.01) A61K 9/107 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/24 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2322805

Preparations for inhalational administration adequate for the inhalational administration of drugs, in particular, hardly water soluble drugs. The above preparations are provided as optionally freeze-dried fat emulsions which are o/w type fat emulsions wherein fat emulsion particles containing an oily component, an emulsifier and a drug as the essential ingredients are dispersed in water, characterized in that the fat emulsion particles have an average particle diameter of from 5 to 100 nm. By using an appropriate inhalator, aerosol particles capable of arriving at pulmonary alveoluses can be easily formed from the inhalants and the particle diameter of the aerosol particles can be easily controlled.

L'invention concerne des préparations destinées à être administrées par inhalation et conçues pour un apport de médicaments, par inhalation, notamment de médicaments difficilement solubles dans l'eau. Ces préparations sont réalisées comme des émulsions huileuses, éventuellement lyophilisées, et sont du type d'émulsions huile dans eau, dans lesquelles les particules d'huile de l'émulsion, contenant un constituant huileux, un émulsifiant et un médicament, en tant que principaux ingrédients, sont dispersées dans de l'eau et sont caractérisées en ce qu'elles possèdent un diamètre particulaire moyen compris entre 5 et 100 nm. A l'aide d'un inhalateur approprié il est possible de former, à partir des substances inhalées, des particules d'aérosol capables d'arriver au niveau des alvéoles pulmonaires, le diamètre particulaire de ces particules d'aérosol pouvant être facilement réglé.

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