C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 33/02 (2006.01) C07C 43/178 (2006.01) C07C 69/007 (2006.01) C07C 69/24 (2006.01) C07C 69/40 (2006.01) C07C 69/587 (2006.01)
Patent
CA 2667153
The present invention relates to a lipid composition comprising at least omega-3 polyunsaturated alcohols, or pro-drugs thereof, which omega-3 polyunsaturated alcohols, or pro-drugs thereof, comprising at least (all-Z)-5,8,11,14,17-eicosapentaen- 1-ol, or pro-drug thereof, and (all-Z)-4,7,10,13,16,19-docosahexaen-1-ol, or pro-drug thereof, and their use as a pharmaceutical, in particular for the treatment of elevated triglyceride levels. The invention also relates to methods for the preparation of these pro-drugs from marine oils.
La présente invention porte sur une composition lipidique comprenant au moins des alcools polyinsaturés oméga-3, ou des pro-médicaments de ceux-ci, lesquels alcools polyinsaturés oméga-3 ou pro-médicaments de ceux-ci comprennent au moins le (tout-Z)-5,8,11,14,17-eicosapentaène-1-ol, ou un pro-médicament de celui-ci, et le (tout-Z)-4,7,10,13,16,19-docosahexaène-1-ol, ou un pro-médicament de celui-ci, et sur leur utilisation comme produits pharmaceutiques, en particulier pour le traitement de taux élevés de triglycérides. L'invention porte également sur des procédés pour la préparation de ces pro-médicaments à partir d'huiles marines.
Holmeide Anne Kristin
Rosman Jenny
Blake Cassels & Graydon Llp
Pronova Biopharma Norge As
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