Fatty-acid amide hydrolase

Details Fatty-acid amide hydrolase Fatty-acid amide hydrolase

C - Chemistry, Metallurgy

12

N

C12N 9/78 (2006.01) A61K 38/46 (2006.01) C07C 49/227 (2006.01) C12N 9/14 (2006.01) C12N 9/80 (2006.01) C12P 7/64 (2006.01)

Patent

CA 2270293

The soporific activity of cis-9,10-octadecenoamide and other soporific fatty- acid primary amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of cis-9,10-octadecenoamide by FAAH leads to the formation of oleic acid, a compound without soporific activity. FAAH has been isolated and the gene encoding FAAH has been cloned, sequenced, and used to express recombinant FAAH. Inhibitors of FAAH are disclosed to block the hydrolase activity.

L'activité soporifique de la cis-9,10-octodécénoamide et d'autres amides primaires d'acides gras est neutralisée par hydrolyse en présence de l'enzyme amide d'acide gras hydrolase (FAAH). L'hydrolyse de cis-9,10-octadécénoamide par l'enzyme FAAH conduit à la formation d'acide oléïque, un composé exempt d'activité soporifique. L'enzyme FAAH a été isolée et le gène codant cette enzyme a été cloné, séquencé et utilisé pour exprimer l'enzyme FAAH recombinée. Cette invention présente des inhibiteurs de l'enzyme FAAH destinés à bloquer l'activité de l'hydrolase.

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