A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/19 (2006.01) A61K 31/20 (2006.01) A61K 31/215 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01) A21D 2/16 (2006.01) A23L 1/30 (2006.01)
Patent
CA 2176719
Delivery to the colon of fatty acids especially Short Chain Fatty Acids (SCFA) can be effected by covalently linking SCFA to a carrier that is preferably a form of carbohydrate, by an ester link. The SCFA is protected by its link with the carbohydrate through the small intestine, and where the carbohydrate is digestible in the small intestine such as a digestive starch, the starch can also be protected from digestion in the small intestine by the substitution. Levels of SCFA such as acetate, propionate and butyrate may be elevated to have beneficial effects in the prevention of colonic disorders such as rectal cancer, diverticulitis, colitis, diarrhea and constipation.
On peut obtenir la diffusion dans le colon d'acides gras, en particulier d'acides gras à chaîne courte (AGCC), en liant par liaison covalente ester un AGCC à un vecteur qui prend de préférence la forme d'un glucide. L'AGCC est protégé par sa liaison avec ce glucide pendant son transit dans l'intestin grêle, et lorsque le glucide est digestible dans l'intestin grêle, dans le cas d'un amidon digestible par exemple, cet amidon peut aussi être protégé de cette digestion par substitution. On peut ainsi élever les niveaux d'AGCC tels que l'acétate, le propionate et le butyrate, ce qui présente l'avantage de contribuer à prévenir les troubles du côlon tels que cancer du rectum, diverticulite, colite, diarrhée et constipation.
Anisson Geoffrey
Illman Richard
Topping David
Commonwealth Scientific And Industrial Research Organisation
Mckay-Carey Mary Jane
LandOfFree
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