Fatty acid esters of lactic acid salts as permeation enhancers

A - Human Necessities – 61 – K

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A61K 47/14 (2006.01) A61K 9/70 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2263334

A transdermal drug delivery system which enhances the delivery of the drug comprises a composition containing, as an enhancer, one or more C5 to C21 fatty acid esters of a lactic acid salt. These compositions are made up of a safe and effective amount of an active pharmaceutical permeant contained in a penetration-enhancing vehicle comprising 0.25 to 50% w. of the fatty acid ester of a lactic acid salt enhancer in a suitable pressure sensitive adhesive carrier vehicle formed from an aqueous emulsion based pressure sensitive adhesive.

Système d'apport transdermique de médicaments permettant d'améliorer l'apport du médicament, comprenant une composition comprenant un activateur, représenté par un ou plusieurs esters d'acides gras C¿5? à C¿21? d'un sel de l'acide lactique. On obtient ces compositions à partir d'une quantité sûre et efficace d'un perméat pharmaceutiquement actif compris dans un véhicule activant la pénétration et contenant de 0,25 à 50 % en poids d'ester d'acide gras d'un activateur du sel de l'acide lactique, renfermé dans un excipient approprié auto-adhésif, que l'on obtient à partir d'un adhésif autocollant à base d'émulsion aqueuse.

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