Fc fusion

Details Fc fusion Fc fusion

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C07K 16/40 (2006.01) C07K 16/46 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2511959

The present invention relates to a simple method for generating antibody-based structures suitable for in vivo use. In particular, the invention relates to a method for the generation of antibody-based structures suitable for in vivo use comprising the steps of: (a) selecting an antibody single variable domain having an epitope binding specificity; and (b) attaching the single domain of step (a) to an effector group. Uses of molecules generated using the method of the invention are also described.

L'invention concerne un procédé simple de production de structures basées sur des anticorps pouvant être utilisées in vivo. Plus particulièrement, cette invention concerne un procédé permettant de produire des structures basées sur des anticorps pouvant être utilisées in vivo comprenant les étapes consistant : (a) à sélectionner un seul domaine variable d'anticorps possédant une spécificité de liaison à l'épitope; et (b) à fixer le domaine de l'étape (a) à un groupe effecteur. Des utilisations de molécules produites au moyen du procédé de l'invention sont également décrites.

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