C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2631630
The invention provides compositions and methods for determining the likelihood of successful treatment with Cetuximab or other equivalent. The methods comprise determining the genomic polymorphism present in a predetermined region of the Fc.gamma.RIIa gene at amino acid position 131 and/or alternatively the Fc.gamma.RIIIa gene at amino acid position 158.
L'invention concerne des compositions et des méthodes destinées à déterminer la probabilité de réussite d'un traitement avec du Cetuximab ou un autre équivalent. Les méthodes consistent à déterminer le polymorphisme génomique présent dans une région prédéterminée du gène Fc.gamma.RIIa en position d'acide aminé 131 et/ou, selon une autre variante, du gène Fc.gamma.RIIIa en position d'acide aminé 158.
Smart & Biggar
University Of Southern California
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