Fc.gamma.riib-specific antibodies and methods of use thereof

Details Fc.gamma.riib-specific antibodies and methods of use thereof Fc.gamma.riib-specific antibodies and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2590935

The present invention relates to antibodies or fragments thereof that specifically bind the extracellular domain of Fc.gamma.RIIB, particularly human Fc.gamma.RIIB, and block the Fc binding site of human Fc.gamma.RIIB. The invention provides methods of treating cancer and/or regulating immune complex mediated cell activation by administering the antibodies of the invention to enhance an immune response. The invention also provides methods of breaking tolerance to an antigen by administering an antigen-antibody complex and an antibody of the invention.

L'invention concerne des anticorps ou des fragments de ces anticorps qui se lient de manière spécifique au domaine extracellulaire de Fc.gamma.RIIB, en particulier au Fc.gamma.RIIB humain, et bloquent le site de liaison Fc de Fc.gamma.RIIB. L'invention concerne également des procédés permettant de traiter le cancer et/ou de réguler l'activité cellulaire médiée par un complexe immunitaire par administration desdits anticorps destinés à renforcer une réponse immunitaire. L'invention concerne enfin des procédés permettant de rompre la tolérance à un antigène par administration d'un complexe antigène-anticorps et un anticorps selon l'invention.

Affiliated with

Also associated with

Rating

Fc.gamma.riib-specific antibodies and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fc.gamma.riib-specific antibodies and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fc.gamma.riib-specific antibodies and methods of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1486604