Fc.gamma.riib-specific antibodies and methods of use thereof

Details Fc.gamma.riib-specific antibodies and methods of use thereof Fc.gamma.riib-specific antibodies and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01) C12N 5/12 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2495251

The present invention relates to antibodies or fragments thereof that specifically bind Fc.gamma.RIIB, particularly human Fc.gamma.RIIB, with greater affinity than said antibodies or fragments thereof bind Fc.gamma.RIIA, particularly human Fc.gamma.RIIA. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.

La présente invention porte sur des anticorps ou des fragments d'anticorps qui se lient spécifiquement au récepteur Fc.gamma.RIIB, en particulier au récepteur Fc.gamma.RIIB humain, avec une affinité plus grande que celle avec laquelle ces anticorps ou ces fragments d'anticorps se lient au récepteur Fc.gamma.RIIA, en particulier au récepteur Fc.gamma.RIIA humain. Cette invention concerne également des procédés permettant de renforcer l'effet thérapeutique d'anticorps thérapeutiques et consistant à administrer lesdits anticorps de la présente invention pour renforcer la fonction effectrice des anticorps thérapeutiques. Cette invention concerne enfin des procédés visant à renforcer l'efficacité d'une composition vaccinale et consistant à administrer les anticorps de la présente invention.

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