Fc receptor modulating compounds and compositions

Details Fc receptor modulating compounds and compositions Fc receptor modulating compounds and compositions

C - Chemistry, Metallurgy

07

C

C07C 323/62 (2006.01) A61K 31/192 (2006.01) A61K 31/277 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2511356

The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the Fc.gamma.RIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

L'invention concerne des composés capables de se lier à un récepteur Fc et d'en moduler l'activité, ces composés comprenant un groupe lipophile principal sous la forme de noyaux aryle substitué par un groupe riche en .PI. électrons. Elle concerne également un procédé de traitement d'une maladie auto-immune au moyen de ces composés et impliquant l'activité du récepteur Fc. Elle concerne aussi un procédé servant à préparer un composé modulant l'activité du récepteur Fc et consistant à : (a) préparer ou à concevoir des composés dont les caractéristiques structurales s'adaptent à un sillon de la structure de Fc.gamma.RIIa; et (b) cribler ces composés afin de rechercher une activité de modulation du récepteur Fc.

Affiliated with

Also associated with

Rating

Fc receptor modulating compounds and compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fc receptor modulating compounds and compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fc receptor modulating compounds and compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1746460