C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/735 (2006.01) C07K 16/28 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2278154
The present invention relates to four novel Fc receptor-like proteins which are members of the Fc Receptor family. In particular, isolated nucleic acid molecules are provided encoding the human FcR-I, FcR-II, FcR-III, and FcR-IV proteins. FcR-I, FcR-II, FcR-III, and FcR-IV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists FcR-I, FcR-II, FcR-III, and FcR-IV activities. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
L'invention porte sur quatre nouvelles protéines de type récepteur Fc, de la famille des récepteurs Fc et en particulier sur des molécules isolées d'acide nucléique codant pour les protéines humaines FcR-I, FcR-II, FcR-III, et FcR-IV. Elle porte également sur des polypeptides FcR-I, FcR-II, FcR-III, et FcR-IV, ainsi que sur des vecteurs, des cellules hôtes, et des méthodes de recombinaison permettant de les produire. L'invention porte en outre sur des méthodes de criblage permettant d'identifier les agonistes et antagonistes des activités des FcR-I, FcR-II, FcR-III et FcR-IV, ainsi que sur des méthodes de diagnostic permettant de détecter les troubles liés au système immunitaire, et des méthodes thérapeutiques de traitement des troubles liés au système immunitaire.
Gentz Reiner L.
Murphy Marianne
Ni Jian
Olsen Henrik S.
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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