Fce fusion proteins for treatment of allergy and asthma

Details Fce fusion proteins for treatment of allergy and asthma Fce fusion proteins for treatment of allergy and asthma

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/395 (2006.01) A61P 37/08 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2455387

The present invention includes Fc.epsilon. fragments conjugated with FC.gamma. fragments, for example, Fc.epsilon.1-Hinge-FcE2-FcE3-FcE4-FCy; Hinge-FcE2-FcE3- FcE4- Fcy; FC.epsilon.2-Fc.epsilon.3-Fc.epsilon.4-FC.gamma. ; FC.epsilon.2- Fc.epsilon.3- Fc.gamma.; FC.epsilon.3-Fc.gamma.; and FC.epsilon.3-Fc.epsilon.4- FC.gamma. , or any derivative or peptide, which has equivalent immunological function. The Fc.gamma. fragment may be a fragment of any of the IgG subclasses (lgG1 I IgG2, IgG3, or IgG4), preferably IgG1 or IgG3, wherein the fragment binds FcyRIIB. The present invention also includes compositions suitable for administering to a patient suffering from an allergic disease comprising the fusion protein construct in a pharmaceutical composition including, for example, an excipient, diluant, or carrier. This treatment may be combined with anti-IgE therapy or allergen immunotherapy.

L'invention concerne des fragments Fc.epsilon. combinés avec des fragments FC.gamma., par exemple, Fc.epsilon.1-(charnière)-Fc.epsilon.2-Fc.epsilon.3-Fc.epsilon.4-FCy; (charnière)-Fc.epsilon.2-Fc.epsilon.3-Fc.epsilon.4- Fcy; FC.epsilon.2-Fc.epsilon.3-Fc.epsilon.4-FC.gamma.; FC.epsilon.2-Fc.epsilon.3- Fc.gamma.; FC.epsilon.3-Fc.gamma.; et FC.epsilon.3-Fc.epsilon.4-FC.gamma., ou tout dérivé ou peptide, qui présente une fonction immunologique équivalente. Le fragment de Fc.gamma. peut être issu de toute sous-classe d'IgG (lgG1 I IgG2, IgG3, ou IgG4), de préférence IgG1 ou IgG3, ce fragment se liant au récepteur Fc.gamma.. L'invention concerne également des compositions destinées à être administrées à des patients souffrant d'allergie, qui comprennent la construction de protéine de fusion dans une composition pharmaceutique comportant par exemple, un excipient, un diluant, ou un vecteur. Ce traitement peut être combiné à un traitement anti-IgE ou à une immunothérapie allergénique.

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