Fcgr3a gebotype and methods for evaluating treatment...

Details Fcgr3a gebotype and methods for evaluating treatment... Fcgr3a gebotype and methods for evaluating treatment...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2569196

The present invention relates to methods and compositions to evaluate or assess the response and/or side effects of a subject to particular therapeutic treatment. More particulary, the invention provides methods to determine the response and/or side effects of subjects, or to adapt the treatment protocol of subjects treated with therapeutic antibodies in situations where target neutralisation is desired without depletion of a target cell. The invention is based on a determination of the FCGR3A genotype of a subject. Preferably, the therapeutic antibodies are antibodies or proteins comprising Fc portions of the G4 subclass.

La présente invention concerne des méthodes et des compositions permettant d'évaluer ou d'aprécier chez un sujet la réponse et/ou les effets secondaires provoqués par un traitement. Plus particulièrement, l'invention concerne des méthdodes et/ou des effets secondaires chez un tel sujet, ou bien l'adaptation du protocole thlérapeutique chez des sujets traités au moyen d'anticorps dans des situations où l'on souhaite une neutralisation de la cible sans déplétion de la cellule visée. L'invention repose sur la détermination du génotype <i>FCGR3A </i> d'un sujet. Les anticorps utilisés à des fins thérapeutiques sont de préférence des anticorps ou des protéines comprenant des parties Fc de la sous-classe G4.

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