C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/735 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2488775
The present invention provides a Fc.gamma.RIIa transgenic non-human animal model for autoimmune disease, particularly arthritis. This invention also provides a method of using this model to screen compounds that can reduce aberrant immune activity including aberrant immune complex formation aberrant immune complex clearance and immune complex induced inflammation. This invention also provides means of using this model to treat or prevent autoimmune disease.
La présente invention concerne un modèle animal transgénique de Fc.gamma.RIIa pour affection auto-immune, en particulier l'arthrite. L'invention concerne également un procédé d'utilisation de ce modèle pour la recherche systématique de composés qui peuvent réduire l'activité immune aberrante, y-compris la formation de complexes immunitaires aberrants, la clairance de complexes immunitaires aberrants, et l'inflammation induite par des complexes immunitaires. L'invention concerne aussi des moyens permettant d'utiliser ce modèle pour traiter ou prévenir une affection auto-immune.
Hogarth Phillip Mark
Mottram Patricia Lesley
Sardjono Caroline Tan
Arthron Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Trillium Therapeutics Inc.
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