Fecal occult blood test reagents and methods

Details Fecal occult blood test reagents and methods Fecal occult blood test reagents and methods

G - Physics

01

N

150/11, 150/3.1

G01N 21/78 (2006.01) C12Q 1/28 (2006.01) G01N 33/72 (2006.01)

Patent

CA 1322323

FECAL OCCULT BLOOD TEST REAGENTS AND METHODS Abstract of the Disclosure An improved method for detecting peroxidatively active materials in a sample is provided, the method incorporating antimalarial drugs such as quinine, quinidine, chloroquine, primaquine, and quinacrine as modulating compounds. In a preferred embodiment, the method is a fecal occult blood test (FOBT), in which a fecal specimen is contacted with chromogen and a hydroperoxide in the presence of a selected quinoline derivative. The method enables careful modulation of test sensitivity and specificity, and further provides an FOBT in which interference from dietary meat ingestion is substantially eliminated.

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