Feline infectious peritonitis vaccine

Details Feline infectious peritonitis vaccine Feline infectious peritonitis vaccine

C - Chemistry, Metallurgy

12

N

C12N 15/50 (2006.01) A61K 39/215 (2006.01) C07K 14/165 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2198743

The invention comprises the nucleotide sequences comprising the FIPV S gene, or a fragment of this gene, which are modified in at least one of the antigenic regions Al and A2 which are involved in enhancement, as well as the use of these sequences for the expression of modified proteins, and for the construction of recombinant viruses or expression plasmids, and the use of the recombinant viruses as vaccines against feline infectious peritonitis, the use of the expression plasmids as immunizing composition by direct injection of the said plasmids into cats, and the use of the modified proteins as vaccine.

L'invention comprend les séquences nucléotidiques comprenant le gène FIPV S, ou un fragment de ce gène, modifiées dans l'une au moins des régions antigéniques A1 et A2 impliquées dans la facilitation, ainsi que l'utilisation de ces séquences pour l'expression de protéines modifiées, et pour la construction de virus recombinants ou de plasmides d'expression, et l'utilisation des virus recombinants comme vaccins contre la péritonite infectieuse féline, l'utilisation des plasmides d'expression comme composition immunisante par injection directe desdits plasmides chez le chat, et l'utilisation des protéines modifiées comme vaccin.

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