Fentanyl composition for nasal administration

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4468 (2006.01) A61K 9/08 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2417727

The treatment of acute pain with a sufficient dosage by intranasal administration of fentanyl results in a time to onset of action comparable to intravenous administration and a significantly faster onset of action than nasal titration of fentanyl. The nasal administration of a sufficient amount of fentanyl to obtain pain relief has lower maximum plasma concentrations comparable to intravenous administration and results in lower rates of adverse events like respiratory depression, nausea and vomiting. Compositions fur use in the method are also disclosed.

Selon l'invention, un traitement de douleurs aiguës avec une dose suffisante de fentanyl, administrée par voie nasale, déploie ses premiers effets rapidement et est comparable à l'administration intraveineuse; ce traitement produit ses effets beaucoup plus rapidement que le titrage nasal de fentanyl. L'administration nasale d'une quantité suffisante de fentanyl pour soulager la douleur permet d'obtenir des concentrations dans le plasma plus faibles, comparables à celles obtenues lors d'une administration intraveineuse, et produit un nombre moins élevé d'effets indésirables tels que la dépression respiratoire, les nausées et vomissements. L'invention concerne aussi des compositions destinées à l'utilisation du procédé.

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