A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4468 (2006.01) A61K 9/16 (2006.01) A61K 47/30 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2345064
A pharmaceutical composition for the treatment of acute pain by sublingual administration is described. The composition comprises an essentially water-free, ordered mixture of fentanyl or a pharmaceutically acceptable salt thereof in the form of microparticles which are adhered to the surface of carrier particles which are substantially larger than the particles of fentanyl, and are essentially water-soluble. In a preferred embodiment, the composition also contains a bioadhesion and/or mucoadhesion promoting agent. The invention also relates to the preparation of the composition, and to the use of the composition for the treatment of acute pain.
L'invention porte sur une composition pharmaceutique destinée à traiter les douleurs aiguës par administration sublinguale. Cette composition comprend un mélange ordonné, essentiellement exempt d'eau, de fentanyl ou d'un sel pharmaceutiquement acceptable de celui-ci se présentant sous forme de microparticules collées aux surfaces des particules porteuses qui sont sensiblement plus grosses que les particules de fentanyl, et qui sont principalement solubles dans l'eau. Selon une réalisation préférée, la composition comprend également un agent favorisant la bioadhésion et/ou la mucoadhésion. Cette invention porte également sur un procédé de préparation de la composition et sur l'utilisation de cette composition dans le traitement des douleurs aiguës.
Hedner Thomas
Lennernas Bo
Lennernas Hans
Nystrom Christer
Pettersson Anders
Diabact Ab
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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