Fentanyl-containing adhesive preparation for external use

Details Fentanyl-containing adhesive preparation for external use Fentanyl-containing adhesive preparation for external use

A - Human Necessities

61

K

A61K 31/4468 (2006.01) A61K 9/70 (2006.01) A61K 47/06 (2006.01) A61K 47/14 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2761600

Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.

La présente invention concerne une préparation adhésive contenant du fentanyl destinée à un usage externe, dans laquelle une couche adhésive est stratifiée sur un corps de support. La couche adhésive contient un copolymère séquencé styrène-isoprène-styrène, une résine donnant du collant qui est composée d'une résine de colophane et d'une résine terpénique, et un agent adoucissant qui est composé d'un polybutène et d'une paraffine liquide. La couche adhésive contient également du fentanyl comme principe actif. La préparation adhésive contenant du fentanyl destinée à un usage externe présente une excellente pénétration dans la peau du fentanyl et une stabilité élevée de la préparation, sans subir de cristallisation du fentanyl pendant le stockage.

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