Fenugreek seed bio-active compositions and methods for...

A - Human Necessities – 61 – K

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A61K 36/48 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2483882

A composition of bio-active compounds and methods for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells. Preferably, the composition of bio-active compounds include 4- hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, gamma-amino butyrate, and trimethylhistidine. In one presently preferred embodiment of the present invention, the bio-active compounds are extracted from fenugreek seeds. A method for extracting a composition of bio-active compounds from fenugreek seeds is also disclosed, wherein the method comprises the steps of: (1) providing a plurality of fenugreek seeds; (2) preparing the fenugreek seeds; and (3) extracting a composition of bio-active compounds from the fenugreek seeds, wherein the bio-active compounds comprise 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, gamma-amino butyrate, and trimethylhistidine. The composition of bio-active compounds and methods for extraction of same preferably include between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids.

La présente invention concerne une composition de composés bioactifs et des procédés pour faciliter et assister le métabolisme et le transport de glucose et de glucides dans des cellules musculaires. La composition de composés bioactifs comprend de préférence de la 4-hydroxyisoleucine et un ou plusieurs acides aminés choisis parmi arginine, aspartate, thréonine, sérine, glutamate, proline, glycine, alanine, cystéine, valine, méthionine, isoleucine, leucine, tryptophane, phénylalanine, ornithine, lysine, histidine, gamma-amino butyrate et triméthylhistidine. Dans un mode de réalisation préféré de la présente invention, les composés bioactifs sont extraits de graines de fenugrec. La présente invention concerne également un procédé pour extraire une composition de composés bioactifs de graines de fenugrec. Ce procédé consiste (1) à disposer d'une pluralité de graines de fenugrec, (2) à préparer les graines de fenugrec et (3) à extraire une composition de composés bioactifs des graines de fenugrec. Ces composés bioactifs comprennent de la 4-hydroxyisoleucine et un ou plusieurs acides aminés choisis parmi arginine, aspartate, thréonine, sérine, glutamate, proline, glycine, alanine, cystéine, valine, méthionine, isoleucine, leucine, tryptophane, phénylalanine, ornithine, lysine, histidine, gamma-amino butyrate et triméthylhistidine. La composition de composés bioactifs et les procédés d'extraction de celle-ci comprennent de préférence entre environ 10 % et 70 % de 4-hydroxyisoleucine et entre environ 20 % et 40 % d'acides aminés.

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