Fermentation of clavulanic acid at a controlled level of...

Details Fermentation of clavulanic acid at a controlled level of... Fermentation of clavulanic acid at a controlled level of...

C - Chemistry, Metallurgy

12

P

C12P 17/18 (2006.01) A61K 31/43 (2006.01) C07D 503/00 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2342181

A method for the production of clavulanic acid by the fermentation of a clavulanic acid producing microorganism at a controlled level of at least 50 mg/l ammonia has been provided for. Under the application of these reaction conditions surprisingly high production levels of clavulanic acid have been obtained.

L'invention se rapporte à un procédé de production d'acide clavulanique par fermentation d'un micro-organisme susceptible de produire de l'acide clavulanique à un niveau régulé d'au moins 50 mg/l d'ammoniac. Le respect de ces conditions de réaction permet d'obtenir de hauts niveaux de production d'acide clavulanique.

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