Fermentation process using specific oxygen uptake rates as a...

Details Fermentation process using specific oxygen uptake rates as a... Fermentation process using specific oxygen uptake rates as a...

C - Chemistry, Metallurgy

12

P

C12P 1/00 (2006.01) C12N 1/16 (2006.01) C12N 9/04 (2006.01) C12N 15/81 (2006.01) C12P 1/02 (2006.01) C12P 7/00 (2006.01) C12P 7/56 (2006.01)

Patent

CA 2487116

Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.

Ce procédé consiste à utiliser la consommation spécifique en oxygène en tant que paramètre de régulation de processus dans les processus de fermentation. Ce procédé consiste à déterminer la consommation en oxygène pendant la dernière phase de production d'un procédé de fermentation, et à réguler les paramètres de traitement de manière à maintenir la consommation d'oxygène dans des plages souhaitées. Cette invention est applicable en particulier lorsque la fermentation est effectuée au moyen d'un micro-organisme comportant un mécanisme pyruvate décarboxylase naturel qui a subi une rupture de sorte qu'il ne fonctionne plus. Les micro-organismes de ce type ont souvent une faible productivité dans des conditions strictement anaérobies. Une microaération régulée par surveillance de la consommation en oxygène permet d'optimiser la performance de ces micro-organismes.

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