Fermentation processes for cultivating streptococci and...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 1/20 (2006.01) A61K 39/04 (2006.01) C12P 19/04 (2006.01)

Patent

CA 2708878

This invention is in the field of bacterial cultures, and specifically relates to the optimization of culture conditions to improve the production of bacterial capsular polysaccharides from Streptococcus strains in fed batch culture and to novel purification methods suitable for production scale purification of bacterial capsular polysaccharides from Streptococcus strains resulting in higher levels of purity than previously obtained for production scale.

La présente invention concerne le domaine des cultures bactériennes, et concerne spécifiquement l'optimisation de conditions de culture pour améliorer la production de polysaccharides capsulaires bactériens à partir de souches de Streptococcus (CPS) en culture à écoulement discontinu. L'invention concerne également des nouveaux procédés de purification adaptés pour la purification à l'échelle industrielle de polysaccharides capsulaires bactériens à partir de souches de Streptococcus résultant en des niveaux plus élevés de pureté que ceux précédemment obtenus à l'échelle industrielle.

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