Fermentative preparation of l-leucine

C - Chemistry – Metallurgy – 12 – P

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195/134.7

C12P 13/06 (2006.01)

Patent

CA 1192156

Reference 6022 FERMENTATIVE PREPARATION OF L-LEUCINE Abstract of the Disclosure L-leucine is prepared by cultivation of an analogue- resistant mutant of Arthrobacter citreus in an aqueous nutrient medium under aerobic conditions. The cultivation is preferably carried out at about 30°C and at a pH of 5 to 0.8. L-leucine is recovered from the fermentation broth. In a preferred embodiment the mutant is further mutated, and the second mutant is similarly fermented to prepare L-leucine.

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