H - Electricity – 01 – F
Patent
H - Electricity
01
F
H01F 1/44 (2006.01) A61K 49/18 (2006.01) H01F 1/00 (2006.01)
Patent
CA 2526967
The invention relates to aqueous dispersions, comprising particles based on a magnetic iron oxide with dimensions of <= 20 nm, the surface of which is modified by the grafting of aminated groups R with a covalent bonding to the surface of said particles, wherein the isoelectronic point of particles with such a modified surface is >= 10. The invention further relates to a method for production of said aqueous suspensions and a method for modification of the surface of the particles present in said dispersions, in particular, by the immobilisation of polysaccharides such as dextrans, particularly for the formulation of magnetic compositions which may be administered in vivo and in particular for the formulation of injectable compositions of contrast agents for MRI.
La présente invention concerne des dispersions aqueuses comprenant des particules à base d'un oxyde de fer magnétique, de dimensions inférieures ou égale à 20 nm, dont la surface est modifiée par le greffage de groupements aminés R liés de façon covalente à la surface desdites particules, dans laquelle le point isoélectrique des particules de surface ainsi modifiée est supérieur ou égal à 10. L'invention concerne également un procédé de préparation de ces suspensions aqueuses, ainsi qu'un procédé de modification de la surface des particules présentes dans ces dispersions, en particulier par immobilisation de polysaccharides tels que des dextranes, notamment pour la formulation de compositions magnétiques administrables in vivo, et en particulier pour la formulation de compositions injectables d'agents de contraste pour l'IRM.
Duguet Etienne
Mornet Stephane
Portier Joseph
Centre National de La Recherche Scientifique (c.n.r.s.)
Robic
LandOfFree
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