Fetal rna in amniotic fluid to determine gene expression in...

Details Fetal rna in amniotic fluid to determine gene expression in... Fetal rna in amniotic fluid to determine gene expression in...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/11 (2006.01) C12Q 1/00 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01)

Patent

CA 2513028

The present invention provides improved methods of prenatal diagnosis, monitoring, screening and/or testing. The invention is based, at least in part, on the discovery that amniotic fluid is a rich source of cell-free fetal RNA. Methods of isolation and analysis of fetal RNA are described, that can lead to information about fetal gene expression that is not available by other techniques. The inventive systems allow for a more comprehensive determination of a living human fetus' health, growth and development and for the prenatal diagnosis of a variety of diseases and conditions.

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