Fgf-21 fusion proteins

Details Fgf-21 fusion proteins Fgf-21 fusion proteins

C - Chemistry, Metallurgy

07

K

C07K 14/50 (2006.01) A61K 38/18 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2565300

The invention provides specific FGF-21 compounds fused to specific IgG4-Fc or HSA derivatives resulting in fusion proteins that are biologically active with an extended elimination half-life and a slower clearance. These FGF-21 compound fusion proteins and compositions are useful in treating type 2 diabetes, obesity, and metabolic syndrome.

L'invention fournit des composés spécifiques FGF-21 fusionnés aux dérivés spécifiques IgG4-Fc ou HSA résultant dans des protéines de fusion qui sont biologiquement actives avec une demi-vie et une clairance plus lente. Ces protéines de fusion de composés et de compositions sont utiles dans le traitement du diabète de type 2, de l'obésité et du syndrome métabolique

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