Fgf2-binding peptides and uses thereof

Details Fgf2-binding peptides and uses thereof Fgf2-binding peptides and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/71 (2006.01) A61K 38/18 (2006.01) A61P 35/00 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2637295

FGF2-binding peptides are here described, which have been designed starting from the N-terminal region of PTX3, in particular spanning the PTX3(82-110) region. Synthetic peptides related to this sequence are able to bind FGF2 and to inhibit its pro-angiogenic activity in vitro and in vivo with no anticipated impact on innate immunity.

L~invention a pour objet des peptides liant le FGF2, conçus à partir de la région N terminale de PTX3, et en particulier de la région couvrant la région (82-110) de PTX3. Les peptides synthétiques liés à cette séquence peuvent lier le FGF2 et inhiber son activité pro-angiogénique in vitro et in vivo sans impact anticipé sur l~immunité naturelle.

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