A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) C07K 14/71 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 5/20 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2473810
The present invention relates to the use of Fibroblast-Growth Factor Receptor (FGFR) agonists for the diagnosis, prevention and/or treatment of pathological conditions including, but not limited to hyperproliferative disorders, bone diseases and vascular diseases. Particularly, the use of FGFR-4 agonists, e.g. anti-FGFR-4 antibodies is described. Further, the invention relates to a pharmaceutical composition comprising the agonist as described above and a screening procedure.
La présente invention concerne l'utilisation d'agonistes du récepteur de facteur de croissance de fibroblaste (FGFR) pour diagnostiquer, prévenir et/ou traiter les états pathologiques comprenant, entre autres, les troubles d'hyperprolifération, les maladies osseuses et les troubles vasculaires. L'invention concerne en particulier l'utilisation d'agonistes de FGFR-4 agonistes, par ex. d'anticorps anti-FGFR-4. L'invention a également pour objet une composition pharmaceutique comprenant l'agoniste mentionné ci-dessus et une procédure de criblage.
Bange Johannes
Ullrich Axel
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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